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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 416-420 doi: 10.1007/s11684-012-0224-4

Abstract:

Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acutelymphoblastic leukemia (B-ALL).In children, T-ALL usually has a worse prognosis than B-ALL, although childhood T-ALL prognoses haveThis novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic

Keywords： acute lymphoblastic leukemia     early T precursor     prognosis    

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvementDeeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemiacancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood

Keywords： pharmacogenomics     acute lymphoblastic leukemia     genomics     pharmacogenetics    

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comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acutelymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acutelymphoblastic leukemia.

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 518-526 doi: 10.1007/s11684-022-0958-6

Abstract: Venous thromboembolism (VTE) is a complication in children with acute lymphoblastic leukemia (ALL).

Keywords： acute lymphoblastic leukemia     child     venous thromboembolism     epidemiology     clinical characteristic     risk    

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical

Keywords： acute lymphoblastic leukemia     molecular therapeutics     targeted therapy     tyrosine kinase inhibitors     immunotherapy    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acutelymphoblastic leukemia

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 229-238 doi: 10.1007/s11684-017-0506-y

Abstract:

A CALLG2008 protocol was developed by the Chinese Acute Lymphoblastic Leukemia Cooperative Group foradult acute lymphoblastic leukemia (ALL).

Keywords： Philadelphia chromosome     acute lymphoblastic leukemia     imatinib     CALLG2008    

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Diagnosis-related Groups (DRGs)-based payment reform to bring benefits to patient care: A case study of leukemia

Zhi-Ruo ZHANG PhD, Jian-Qing MI MD, Zhao-Jun WEN MA, Sai-Juan CHEN MD, PhD, Zhu CHEN PhD, Long-Jun GU MD, Jing-Yan TANG MD, PhD, Shu-Hong SHEN MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 8-15 doi: 10.1007/s11684-010-0018-5

Abstract: the level of reimbursement from insurance is very limited, especially for critical diseases such as leukemiaTreatments of acute promyelocytic leukemia at Rui-Jin Hospital, and childhood acute lymphoblastic leukemia

Keywords： healthcare reform     diagnosis-related groups     clinical paths     comparative effectiveness analysis     acute promyelocyticleukemia     childhood acute lymphoblastic leukemia    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.

Keywords： acute myeloid leukemia     mutations     risk stratification    

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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia.directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemiacells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the diseasea potentially curable type of leukemia.

Keywords： acute promyelocytic leukemia     arsenic     all-trans retinoic acid     survival    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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expression pattern of mutations coordinated by target repression and promoter hypermethylation in acutemyeloid leukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocyticleukemia

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identified

Keywords： acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: However, little is known about the role of ACSL5 in acute myeloid leukemia (AML).

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acuteleukemia post-chemotherapy plus modified donor lymphocyte infusion

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 728-739 doi: 10.1007/s11684-021-0833-x

Abstract: However, little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia

Keywords： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor    

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Title Author Date Type Operation

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Journal Article

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acutelymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia

Journal Article

Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Journal Article

Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acutelymphoblastic leukemia

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Journal Article

Diagnosis-related Groups (DRGs)-based payment reform to bring benefits to patient care: A case study of leukemia

Zhi-Ruo ZHANG PhD, Jian-Qing MI MD, Zhao-Jun WEN MA, Sai-Juan CHEN MD, PhD, Zhu CHEN PhD, Long-Jun GU MD, Jing-Yan TANG MD, PhD, Shu-Hong SHEN MD, PhD,

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

expression pattern of mutations coordinated by target repression and promoter hypermethylation in acutemyeloid leukemia

Journal Article

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocyticleukemia

Journal Article

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acuteleukemia post-chemotherapy plus modified donor lymphocyte infusion

Journal Article